Testing the rate of creatinine clearance shows the kidneys' ability to filter the blood. Your doctors may order creatinine clearance tests to check renal (kidney) function. The formulas used are gender specific: CrCl for men (140 - age) x Weight in kg / (Serum Creatinine in mg/dL x 72) CrCl for women (140 - age) x Weight in kg x. Weight is the numerical value in kilograms. The above calculator requires the patient’s gender, age, height and weight and the serum creatinine. Creatinine Clearance Sex ( (140 - Age) / (SerumCreat)) (Weight / 72) The numerical value of sex is 1 for males and 0.85 for females. Generally, the creatinine clearance is a good estimation of the glomerular filtration rate. The most common method to determine it is via the Cockcroft Gault equation. The GFR can vary depending on age, sex, and size.
#CREATININE CLEARANCE PCALC FREE#
Creatinine clearance in a healthy young person is about 125 milliliters per minute - meaning each minute, that person's kidneys clear 125 mL of blood free of creatinine. Creatinine Clearance (ml/min) (140 - Age) x Weight (kg) x constant Serum Creatinine (mol/L) Constant 1.23 for male and 1.04 for female Accuracy of Cockcroft-Gault estimation is influenced by bodyweight The Cockcroft-Gault equation estimates CrCl using the patient’s age, weight, gender and serum creatinine. The amount of blood the kidneys can make creatinine-free each minute is called the creatinine clearance. The kidneys filter creatinine from the blood into the urine, and reabsorb almost none of it. The functioning of this tool and the content on this page have been verified by iCliniq medical review team.Ĭreatinine is a waste product that is produced continuously during normal muscle breakdown. Doses of some drugs may need to be adjusted.Ĭomplete and accurately timed urine collections are essential.Creatinine Clearance Calculator (Estimate by Cockcroft-Gault Equation) CrCl (140 - age) x AjBW / (Scr x 72) Note: (Multiply result by 0.85 for females) AjBW adjusted body weight: AjBW IBW + 0. This may indicate acute or chronic kidney disease. Cockcroft and Gault equation utilizing the adjusted body weight to calculate an estimated creatinine clearance. Reduced creatinine clearance is an indicator of reduced glomerular filtration rate (GFR). Measured creatinine clearance is of particular use in patients with extremes of body size or composition where estimation formulae may be unreliable. The Cockroft-Gault Equation typically overestimates creatinine clearance by approximately 10 to 30. Typically falling approx 0.5 mL/min per year at ages over 30 years.Ĭreatinine clearance is a marker of glomerular filtration rate (GFR). Cockcroft-Gault CrCl (140-age) x (Wt in kg) x (0.85 if female) / (72 x Cr) Note: The original Cockroft-Gault Equation listed here provides an estimate of creatinine clearance, but this original formula is not adjusted for body surface area and may be less accurate in obese patients.
The patient should not eat meat at the meal immediately prior to, or during, the procedure.Ī calculated value using serum and urine creatinine.Ĭreatinine clearance (mL/min) = urine creatinine (mmol/L) x urine volume (mL) x 16.7 / plasma creatinine (mmol/L) x duration of collection (hours) The patient's height and weight may be measured so that surface area can be calculated and creatinine clearance adjusted to the 'standard' body surface area of 1.73m 2 if required.Ĭreatinine clearance may be estimated rather than measured -see Creatinine clearance Cockcroft and Gault. Reference range in our laboratory of an 'uncorrected' creatinine clearance for an adult male is 90-139 mL/minute, and for an adult female is 80-125 mL/minute. Serum and timed urine collection for creatinine measurements see Creatinine urine.